Semen DNA Fragmentation Test: What You Need to Know

What is the Semen DNA Fragmentation Test?

The Semen DNA Fragmentation Test is an advanced diagnostic test that evaluates the integrity of the genetic material (DNA) within a man’s sperm. Unlike standard semen analysis—which looks at sperm count, motility, and morphology—this test measures the level of DNA damage or fragmentation in sperm cells.

Who Needs Semen DNA Fragmentation Test?

This test is recommended for men who:

• Have unexplained infertility, despite normal semen analysis results

• Have experienced recurrent pregnancy loss or failed IVF/ICSI cycles

• Are of advanced paternal age (typically over 40)

• Have been exposed to environmental toxins, radiation, or heat

• Have a history of varicocele or have undergone varicocelectomy

• Suffer from chronic infections, inflammation, or oxidative stress

• Are planning for assisted reproductive techniques (ART) and want to assess sperm quality beyond conventional parameters

Why is it Semen DNA fragmentation Test Done?

Sperm DNA integrity is crucial for:

• Successful fertilization

• Proper embryo development

• Reduced risk of miscarriage

• Better outcomes in ART like IVF and ICSI

Even if a man has a normal sperm count, high levels of DNA fragmentation may impair the ability to conceive or maintain a healthy pregnancy.

Purpose of the Semen DNA Fragmentation Test

The main goals of the Semen DNA Fragmentation Test are to:

• Identify hidden causes of male infertility

• Assess the likelihood of natural conception

• Improve success rates in IVF/ICSI treatments

• Decide if sperm retrieval techniques like testicular sperm extraction (TESE) might be more effective

• Evaluate the impact of lifestyle, medications, or medical conditions on sperm quality

Normal Range and Interpretation

Results are typically given as a DNA Fragmentation Index (DFI). The ranges may vary slightly depending on the laboratory and the method used (e.g., SCSA, TUNEL, COMET, or SCD/Halosperm). Generally:

• DFI < 15%: Excellent DNA integrity (low risk)

• DFI 15–25%: Moderate DNA fragmentation (possible fertility issues)

• DFI > 25%: High DNA fragmentation (significant risk of infertility or miscarriage)

Symptoms Indicating the Need for This Test

Since DNA fragmentation does not cause visible symptoms, the test is usually considered when:

• The couple faces delayed conception despite regular, unprotected intercourse

• There are recurrent miscarriages

• Previous ART procedures like IVF or ICSI have failed

• Male partner has conditions like varicocele, diabetes, or has undergone chemotherapy or radiation

• There’s a history of lifestyle risk factors (smoking, alcohol, obesity, etc.)

Where Can You Get This Test Done?

You can get a Semen DNA Fragmentation Test at:

• ONELIFE HOME HEALTH CARE CENTER

How Much is Semen DNA Fragmentation Test Cost ?

-Sperm DNA Fragmentation Test price in dubai ranges between 1500 aed - 1800 aed.